| 2026-06-17 | Wild European rabbit in Australia, e.g. |
| 2026-06-02 | Gnat or nit |
| 2026-04-01 | "Ramona the ___" (Beverly Cleary book) |
| 2026-03-17 | Pain in the butt |
| 2026-03-04 | Minor menace |
| 2025-12-17 | Fly by night ... or by day |
| 2025-11-17 | Nuisance |
| 2025-09-07 | Annoyance |
| 2025-06-20 | Little annoyance |
| 2025-01-31 | Persistent interrupter, say |
| 2024-10-20 | Nag |
| 2024-07-17 | Bother |
| 2024-03-15 | Threat to crops |
| 2023-10-04 | Fly in the face, e.g. |
| 2023-05-21 | Irritating sort |
| 2023-04-10 | Annoying sort |
| 2023-01-31 | Nuisance |
| 2023-01-16 | Irritating sort |
| 2022-12-21 | Target for an exterminator |
| 2022-12-19 | Nuisance |
| 2022-08-13 | ___ control |
| 2022-04-05 | Nuisance |
| 2022-03-26 | Headache |
| 2022-03-05 | Bother |
| 2022-03-02 | Annoyance |
| 2022-02-26 | Noodge |
| 2022-01-30 | Royal pain |
| 2022-01-27 | Dennis the Menace, e.g. |
| 2021-11-26 | Small headache |
| 2021-10-19 | Persistent little sibling, maybe |
| 2020-11-22 | Pain in the neck |
| 2020-11-19 | Roach or termite |
| 2020-04-24 | Boll weevil, for one |
| 2019-12-02 | Boll weevil, to a cotton farmer |
| 2019-10-07 | Little brother, stereotypically |
| 2019-08-11 | Real pain |
| 2019-08-07 | Nuisance |
| 2019-06-22 | Little noodge |
| 2018-08-22 | Termite or gnat |
| 2018-04-22 | Bedbug, e.g. |
| 2018-03-18 | One getting shooed |
| 2018-01-30 | Annoyance |
| 2018-01-07 | Little sibling, often |
| 2017-08-09 | Pain in the you-know-what |
| 2017-04-01 | Obnoxious one |
| 2017-03-12 | Pain in the neck |
| 2017-03-06 | Rat or roach |
| 2016-12-09 | Annoyance |
| 2016-11-05 | Raid target |
| 2016-07-15 | Tick, e.g. |
| 2016-06-25 | Bother |
| 2015-12-10 | Trying type |
| 2015-11-14 | Real pain |
| 2015-11-13 | Garden interloper |
| 2015-01-08 | Nag, e.g. |
| 2014-11-14 | Fly in the face of someone? |
| 2014-07-20 | Bother |
| 2014-04-13 | Nudnik |
| 2013-02-01 | Slug, e.g. |
| 2012-12-17 | Little brother, to an older sibling, say |
| 2012-04-06 | 16-Across, e.g. |
| 2011-08-11 | One who 26-Across |
| 2011-07-29 | Tick, e.g. |
| 2011-05-01 | Unwelcome guest |
| 2010-07-20 | Irksome type |
| 2010-05-17 | Dennis the Menace, for one |
| 2010-05-16 | Pain, so to speak |
| 2010-05-04 | Pain in the neck |
| 2010-03-15 | Cockroach or termite |
| 2010-01-17 | Exterminator's target |
| 2010-01-07 | With 65-Across, extermination ... or what can be done to 10 answers in this puzzle without affecting their clues? |
| 2009-05-06 | Annoying type |
| 2009-04-29 | Orkin victim |
| 2009-02-24 | Real pill |
| 2008-10-25 | Starling, e.g. |
| 2008-10-05 | Mole, e.g. |
| 2007-11-13 | Younger brother, say |
| 2007-09-01 | Raid victim |
| 2007-03-30 | Slug, say |
| 2007-02-12 | Annoyer |
| 2006-08-14 | Mole, to a gardener |
| 2006-06-01 | Irritant |
| 2006-01-16 | Persistent annoyer |
| 2005-10-05 | Buttinsky, e.g. |
| 2005-08-26 | Noodge |
| 2005-08-11 | D-Con target |
| 2005-06-13 | Termite, e.g. |
| 2005-06-09 | Little brother, maybe |
| 2004-09-26 | Annoyance |
| 2004-03-08 | Exterminator's target |
| 2004-02-23 | Nuisance |
| 2003-02-02 | Ant, maybe |
| 2002-12-14 | Bother |
| 2002-02-15 | Pain in the neck |
| 2002-01-30 | Dennis, to Mr. Wilson |
| 2002-01-18 | Fly, e.g. |
| 2001-04-01 | Noodge |
| 2001-03-03 | 43-Down, e.g. |
| 2001-02-11 | Nudnik |
| 2000-10-28 | Bother |
| 2000-10-18 | Cutworm, e.g. |
| 2000-10-01 | Mosquito, e.g. |
| 2000-08-20 | Adamant ant? |
| 2000-07-23 | Fly, e.g. |
| 2000-04-30 | Hanger-on, maybe |
| 2000-04-15 | Buttinsky |
| 2000-01-30 | Noodge |
| 2000-01-23 | Termite, e.g. |
| 2000-01-21 | Pain in the neck |
| 1999-12-25 | Teaser |
| 1999-11-29 | Nuisance |
| 1999-08-02 | Nuisance |
| 1999-06-23 | Nudnik |
| 1999-02-01 | Botherer |
| 1998-12-03 | Irk-aholic? |
| 1998-11-10 | Annoyance |
| 1998-08-21 | Plague |
| 1997-08-11 | Buzzy one |
| 1996-09-22 | Nudnik |
| 1996-05-29 | Bother |
| 1995-09-06 | Nudnik |
| 1995-05-14 | Pain, so to speak |
| 1995-04-30 | Pain in the neck |
| 1994-09-18 | Weevil, for one |
| 1994-05-03 | Annoyance |
| 1994-05-01 | Nudge |
| 1994-02-25 | Pain of a sort |
| 1993-12-19 | Nudnik |