| 2024-11-21 | Major highway through the southern U.S. |
| 2019-10-18 | Main lower artery, informally |
| 2018-02-12 | Major Calif.-to-Fla. route |
| 2018-01-23 | Calif.-to-Fla. route |
| 2017-09-28 | Cross-country route, informally |
| 2017-07-13 | Major thoroughfare through Houston, informally |
| 2014-05-22 | Southern hwy. |
| 2014-01-24 | Christopher Columbus Transcontinental Hwy. |
| 2013-08-12 | Major Fla.-to-Calif. route |
| 2013-03-03 | Calif.-to-Fla. hwy. |
| 2012-10-15 | Major Calif.-to-Fla. route |
| 2012-01-15 | Major artery through San Antonio |
| 2011-01-20 | L.A.-to-Jacksonville rte. |
| 2008-06-07 | Eight-state coast-to-coast rte. |
| 2007-05-15 | Major Calif.-to-Fla. route |
| 2007-03-13 | Tucson-to-New Orleans route |
| 2006-11-19 | Highway damaged by hurricane Katrina |
| 2006-03-16 | Coast-to-coast hwy. |
| 2005-10-13 | Calif.-Fla. route |
| 2005-04-24 | Route west of Jacksonville, Fla. |
| 2004-06-04 | L.A.-to-Jacksonville route |
| 2000-11-21 | Major Calif.-to-Fla. route |